FKBP12 Protein, Human (His)

FKBP12 protein maintains TGFBR1 in an inactive state, inhibits activin signaling by recruiting SMAD7, and modulates RYR1 calcium channel activity. As a PPIase, it speeds up protein folding. FKBP12's multifunctionality underscores its regulatory role in cellular processes, emphasizing its importance in signaling and protein folding. FKBP12 Protein, Human (His) is the recombinant human-derived FKBP12 protein, expressed by E. coli , with C-His labeled tag.

FKBP12 protein plays a crucial role in maintaining the inactive conformation of TGFBR1, the serine/threonine kinase receptor for TGF-beta, effectively preventing receptor activation in the absence of ligand. Additionally, FKBP12 recruits SMAD7 to ACVR1B, inhibiting the association of SMAD2 and SMAD3 with the activin receptor complex and thereby blocking activin signaling. This multifunctional protein may also modulate the activity of the RYR1 calcium channel. As a peptidyl-prolyl cis-trans isomerase (PPIase), FKBP12 accelerates the folding of proteins by catalyzing the isomerization of proline imidic peptide bonds in oligopeptides. The diverse functions of FKBP12 highlight its regulatory role in various cellular processes, emphasizing its significance in intracellular signaling and protein folding.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

C-His

P62942/NP_463460.1 (M1-E108)

2280  [NCBI]

Approximately 12.9 kDa.

Greater than 95% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.22 μm filtered solution of PBS, 10% glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.