GAD1/GAD67 Protein, Human (sf9, His)

The GAD1/GAD67 protein utilizes pyridoxal 5'-phosphate as a cofactor and acts as a catalyst in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GAD1 plays a key role in the conversion of glutamate to GABA, a key neurotransmitter involved in regulating neuronal excitability. GAD1/GAD67 Protein, Human (sf9, His) is the recombinant human-derived GAD1/GAD67 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Glutamate Decarboxylase 1 (GAD1), also known as GAD67, is an enzyme that plays a pivotal role in neurotransmission by catalyzing the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GAD1 utilizes pyridoxal 5'-phosphate as a cofactor in the decarboxylation of glutamate to form GABA, a crucial neurotransmitter that regulates neuronal excitability in the central nervous system. The balanced production of GABA by GAD1 is essential for maintaining the inhibitory-excitatory balance in neural circuits and is implicated in various physiological and pathological conditions of the nervous system.

Human

Sf9 insect cells

C-His

Q99259-1 (M1-L594)

2571  [NCBI]

Approximately 64 kDa

Greater than 80% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.