2. Gene
  3. GAS6 - growth arrest specific 6 Gene

GAS6 - growth arrest specific 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AXSF; AXLLG

Gene ID: 2621 | Gene type: protein coding

About GAS6

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,820,549-113,864,076 (from NCBI)

This gene has 5 transcripts (splice variants), 142 orthologues and 3 paralogues. Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues.

Summary

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GAS6 Products(1)

mRNA Protein Name
NM_000820.4 NP_000811.1 growth arrest-specific protein 6 precursor

GAS6 Protein Structure

Gla

Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (53 - 94)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (160 - 195)

EGF_CA

EGF_CA: Calcium-binding EGF domain (197 - 236)

EGF_CA

EGF_CA: Calcium-binding EGF domain (238 - 263)

Laminin_G_1

Laminin_G_1: Laminin G domain (325 - 452)

Laminin_G_2

Laminin_G_2: Laminin G domain (552 - 650)

  • 0
  • 200
  • 400
  • 600
  • 678 a.a.
Protein Preferred Names Protein Names

growth arrest-specific protein 6

AXL receptor tyrosine kinase ligand

Recombinant GAS6 Proteins

Cat. No. Product Name Accession Purity
HY-P70470 GAS6 Protein, Human (HEK293, Fc) Q14393-2 (A31-A678) ≥95%
HY-P70780 GAS6 Protein, Human (HEK293, His) Q14393-2 (A31-A678) ≥95%
HY-P700724 GAS6 Protein, Human (630a.a, HEK293, His) Q14393-2 (A49-A678) ≥95%

Related Diseases

Diseases Alias
Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative

Mesangial Proliferative Gn

Mesangioproliferative Glomerulonephritis

Glomerulonephritis Mesangial Proliferative
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Vitamin K Deficiency Bleeding

Vitamin K Deficiency

Deficiency Of Vitamin K

Vitamin K

Vitamin K Deficiency Hemorrhagic Disease
Glomerulonephritis

Bright'S Disease
Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33

CILD33

Ciliary Dyskinesia, Primary, 33, Without Situs Inversus

Primary Ciliary Dyskinesia 33 Without Situs Inversus
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Parameningeal Embryonal Rhabdomyosarcoma
La Crosse Encephalitis

California Encephalitis

California Virus Encephalitis

Neuroinvasive California Encephalitis Virus Infection

Californian Encephalitis

Encephalitis, California

California Meningoencephalitis

California Encephalitis Virus Infection

California Encephalitis Virus Infection Neuroinvasive Disease

California Meningoencephalitis Virus Disease

California Serogroup Virus Neuroinvasive Disease

California Viral Encephalitis

Ce - [California Encephalitis]

Lac - [La Crosse Encephalitis]
Meckel Syndrome, Type 7

Meckel Syndrome 7

Nphp3-Related Meckel-Like Syndrome

MKS7

Goldston Syndrome

Meckel Syndrome Type 7

Meckel-Like Syndrome Type 1

Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome

Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst

Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst

Meckel-Gruber Syndrome, Type 7

Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99463 Batiraxcept Inhibitor 96.40% Phase 3
HY-P99161 Tilvestamab Inhibitor 98.08% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119039 RU-301 Inhibitor 99.44% Unkown
HY-124066 RU-302 Inhibitor 98.02% Unkown
HY-N2995 Poricoic acid A Modulator 98.08% Unkown
HY-149092 Anticancer agent 109 / Unkown
HY-152075 AXL-IN-14 Inhibitor / Unkown
HY-RS05285 GAS6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GAS6 MGD MGI:95660
Bos taurus GAS6 VGNC VGNC:29261
Macaca mulatta GAS6 VGNC VGNC:72885
Canis familiaris GAS6 VGNC VGNC:41118
Felis catus GAS6 VGNC VGNC:62469
Rattus norvegicus GAS6 RGD RGD:61913
Macaca fascicularis GAS6 NCBI NCBI:102133887
Others GAS6 NCBI