GDF-15 Protein, Canine (His)

The GDF-15 Protein, a significant TGF-beta family member, plays a crucial role in cell growth, differentiation, and immune regulation. Its study enhances understanding of signaling pathways associated with the TGF-beta superfamily and provides insights into its unique contributions to cellular homeostasis. GDF-15's classification within the TGF-beta family underscores its specific role among growth factors. Further exploration promises to enhance our knowledge of its contributions to both normal physiology and disease states, offering potential applications in cancer research, inflammation, and metabolic disorders. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli, with N-His labeled tag. The total length of GDF-15 Protein, Canine (His) is 111 a.a., with molecular weight of 15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition., respectively.

The GDF-15 Protein is a significant member of the TGF-beta family, underscoring its crucial role in diverse cellular processes, including cell growth, differentiation, and immune regulation. As part of this family, GDF-15 likely shares conserved structural and functional features with related proteins, emphasizing its involvement in signaling pathways associated with the TGF-beta superfamily. The classification within the TGF-beta family underscores its specific designation within the broader context of growth factors, providing insights into its unique contributions to cellular homeostasis. The study of GDF-15 contributes to our understanding of its role in various physiological and pathological conditions, offering potential applications in cancer research, inflammation, and metabolic disorders. Further exploration of GDF-15's role holds promise for enhancing our knowledge of its contributions to both normal physiology and disease states.

1. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC₅₀ of 6.7 ng/ml determined by ELISA.
2. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC₅₀ of 48.3 ng/mL determined by ELISA.

Canine

E. coli

N-His

A0A8C0TNP6 (A197-V307)

484822  [NCBI]

ARDGCPLGEGRCCRLQSLRASLQDLGWANWVVAPRELDVRMCVGACPSQFRSANTHAQMQARLHGLNPDAAPAPCCVPASYEPVVLMHQDSDGRVSLTPFDDLVAKDCHCV

15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition.

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of 50 mM HAc, pH 2.9. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in 50mM HAc, pH 2.9.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.