GGPS1 Protein, Human (His)

The GGPS1 protein is responsible for catalyzing the trans-addition of three molecules of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP) to synthesize geranylgeranyl pyrophosphate. This compound is an important precursor for the biosynthesis of carotenoids and geranylated proteins. GGPS1 Protein, Human (His) is the recombinant human-derived GGPS1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GGPS1 Protein, Human (His) is 300 a.a., with molecular weight of ~35.0 kDa.

Geranylgeranyl Pyrophosphate Synthase (GGPS1) is an enzyme that catalyzes the trans-addition of three molecules of isopentenyl pyrophosphate (IPP) onto dimethylallyl pyrophosphate (DMAPP), leading to the formation of geranylgeranyl pyrophosphate (GGPP). GGPP serves as a crucial precursor for the biosynthesis of various important molecules, including carotenoids and geranylated proteins. Carotenoids are essential pigments with antioxidant properties, while geranylated proteins are involved in cellular signaling and regulation. The enzymatic activity of GGPS1 is central to the synthesis of GGPP, providing a key building block for the production of biologically significant compounds. Understanding the functions of GGPS1 offers insights into the regulation of pathways related to pigmentation, antioxidant defense, and cellular signaling.

Human

E. coli

N-6*His

O95749 (M1-E300)

9453  [NCBI]

MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.