GH/Somatotropin Protein, Human (His)

Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-His labeled tag.

The Somatotropin (GH) protein plays a pivotal role in growth control, exerting its primary influence on body growth by stimulating the liver and other tissues to secrete insulin-like growth factor 1 (IGF-1). GH serves as a potent regulator of both the differentiation and proliferation of myoblasts, contributing significantly to the overall growth and development of the organism. Additionally, it plays a crucial role in enhancing amino acid uptake and promoting protein synthesis in muscle and various tissues. Structurally, GH exists in various forms, including monomers, dimers, trimers, tetramers, and pentamers, either disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Furthermore, GH can form complexes with GH binding protein (GHBP) or with the alpha2-macroglobulin complex, underscoring its versatile molecular interactions that contribute to its multifaceted roles in growth regulation and tissue development.

Human

E. coli

N-His

P01241-1 (F27-F217)

2688  [NCBI]

FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Approximately 24.7 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.