GH1 - growth hormone 1 Gene

Homo sapiens

Also known as GH; GHN; GH-N; GHB5; IGHD2; hGH-N; IGHD1A; IGHD1B

Gene ID: 2688 | Gene type: protein coding

About GH1

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,917,203-63,918,839 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 5 paralogues and is associated with 8 phenotypes. Restricted expression toward placenta (RPKM 13.6).

Summary

The protein encoded by this gene is a member of the somatotropin/Prolactin family of Hormones which play an important role in growth control. The gene, along with four Other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth Hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the Other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

GH1 Products(3)

mRNA	Protein	Name
NM_000515.5	NP_000506.2	somatotropin isoform 1 precursor
NM_022559.4	NP_072053.1	somatotropin isoform 2 precursor
NM_022560.4	NP_072054.1	somatotropin isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	7782332	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	1549776	GOA
enables growth factor activity	IPI IPI: Inferred from physical interaction	9360546	GOA
enables growth hormone activity	IDA IDA: Inferred from direct assay	1549776	GOA
enables growth hormone receptor binding	IDA IDA: Inferred from direct assay	6303755	GOA
enables growth hormone receptor binding	IPI IPI: Inferred from physical interaction	1549776	GOA
enables prolactin receptor binding	IDA IDA: Inferred from direct assay	10890569	GOA
enables prolactin receptor binding	IPI IPI: Inferred from physical interaction	7984244	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8943276	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone maturation	IDA IDA: Inferred from direct assay	20110402	GOA
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8063815	GOA
involved in cell surface receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	12552091	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	7782332	GOA
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	1549776	GOA
involved in growth hormone receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12552091	GOA
acts upstream of or within positive regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	9144201	GOA
involved in positive regulation of insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	7565946	GOA
involved in positive regulation of multicellular organism growth	IDA IDA: Inferred from direct assay	7565946	GOA
involved in positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	8496314	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	7782332	GOA
NOT involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	9360546	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8923468	GOA
involved in response to estradiol	IDA IDA: Inferred from direct assay	12552091	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	5810834	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11549663	GOA
part of growth hormone receptor complex	IDA IDA: Inferred from direct assay	1549776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

somatotropin

growth hormone B5

GH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GH1	P01241	GHR	Homo sapiens	P10912	X-Ray Diffraction	9353194
Intra	GH1	P01241	GHR	Homo sapiens	P10912	Fluorescence Spectr	31279174
Intra	GH1	P01241	GHR	Homo sapiens	P10912	X-Ray Diffraction	8943276

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7183	GH/Somatotropin Protein, Human	P01241-1 (F27-F217)	≥95%
HY-P7360	GH/Somatotropin Protein, Human (CHO)	CAA23779.1 (F27-F217)	≥95%
HY-P73085	GH/Somatotropin Protein, Human (His)	P01241-1 (F27-F217)	≥95%
HY-P700610	GH/Somatotropin Protein, Human (N-His, C-Avi)	P01241-1 (F27-F217)	≥95%

Related Diseases

Diseases

Alias

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Kowarski Syndrome

Biodefective Growth Hormone	Pituitary Dwarfism With Normal Immunoreactive Growth Hormone And Low Somatomedin
Short Stature Due To Growth Hormone Qualitative Anomaly	KWKS

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Growth Hormone Deficiency

Somatotropin Deficiency

Isolated Somatotropin Deficiency

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Empty Sella Syndrome

Empty Sella Turcica

Empty Sella

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Laron Syndrome

Growth Hormone Insensitivity Syndrome	Growth Hormone Receptor Deficiency
Laron Dwarfism	Pituitary Dwarfism Ii
Laron-Type Isolated Somatotropin Defect	Primary Growth Hormone Resistance
Laron-Type Dwarfism	Laron Type Pituitary Dwarfism I
Primary Growth Hormone Insensitivity	Primary Gh Resistance
Gh-R Deficiency	Growth Hormone Receptor Defect
Laron-Type Pituitary Dwarfism	Laron-Type Short Stature
Severe Gh Insensitivity	Ghis
Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway	Complete Growth Hormone Insensitivity
Gh Receptor Deficiency	Primary Gh Insensitivity
Short Stature Due To Growth Hormone Resistance	LARS

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Hypopituitarism

Pituitary Hypofunction	Pituitary Insufficiency
Pituitary Hormone Deficiency	Subpituitarism
Hypophyseal Dystrophy	Hypohypophysism
Anterior Pituitary Insufficiency	Deficient Secretion Of One Or More Pituitary Hormones
Hypopituitarism Syndrome	Pituitary Deficiency
Pituitary Failure	Pituitary Insufficiency Nos
Anterior Pituitary Hypofunction	Deficient Secretion Of All Pituitary Hormones
Hypopituitary Dwarfism	Hyposomatotropic Dwarfism
Hypophyseal Dwarfism	Hypopituitary Cachexia
Hypophyseal Short Stature	Panhypopituitarism Syndrome
Pituitary Cachexia	Juvenile Hypopituitarism
Pituitary Dwarfism	Pituitary Gland Hypofunction
Primary Hypopituitarism	Secondary Hypogonadism
Prepubertal Panhypopituitarism	Prepubertal Dwarfism
Postpartum Panhypopituitary Syndrome	Postpartum Hypopituitarism
Pituitary Short Stature	Pituitary Infantilism
Pituitary Hypogonadism	Pituitary Hypoadrenocorticism

Hyperprolactinemia

Chiari-Frommel Syndrome	Hyperprolactinaemia
Familial Hyperprolactinemia	HPRL
Pregnancy-Related A-G Syndrome	Familial Isolated Prolactin Receptor Deficiency

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Pituitary Tumors

Pituitary Tumor

Pituitary Neoplasms

Mccune-Albright Syndrome

Mass Syndrome	Polyostotic Fibrous Dysplasia
MAS	Fibrous Dysplasia Of Bone
Albright Syndrome	Mass Phenotype
Overlap Connective Tissue Disease	Mccune Albright Syndrome
Osteitis Fibrosa Disseminata	OCTD
Albright'S Disease	Pfd
Pofd	Albright'S Syndrome
Mccune-Albright Syndrome, Somatic, Mosaic	Albright'S Disease Of Bone
Albright'S Syndrome With Precocious Puberty	Albright-Mccune-Sternberg Syndrome
Albright-Sternberg Syndrome	Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty
Gonadotropin-Independent Female-Limited Sexual Precocity	Fibrous Dysplasia Polyostotic
Fibrous Dysplasia, Polyostotic

Chromophobe Adenoma

Adenoma, Chromophobe	Chromophobe Adenoma Of The Pituitary Gland
Adenoma Chromophobe

Fibrous Dysplasia

Fibrous Dysplasia Of Bone

Pituitary Hormone Deficiency, Combined, 2

Panhypopituitarism	Combined Pituitary Hormone Deficiency
CPHD2	Ateliotic Dwarfism With Hypogonadism
Pituitary Dwarfism Iii	Hanhart Dwarfism
Simmond'S Disease	Simmonds' Disease
Cphd	Pituitary Hormone Deficiency, Combined
Hormone Deficiency, Pituitary, Combined, Type 2	Pituitary Dwarfism Type 3
Sheehan Syndrome

Hypothalamic Disease

Hypothalamic Diseases	Hypothalamic Dysfunction
Hypothalamic Disorder	Hypothalamic Dysfunction Syndromes

Precocious Puberty

Familial Precocious Puberty	Idiopathic Sexual Precocity
Sexual Precocity	Puberty Precocious
Cryptogenic Sexual Precocity

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Pituitary Adenoma

Adenoma Of The Pituitary Gland	Pituitary Adenomas
Adenoma, Pituitary	Pituitary Gland Adenoma
Pituitary Neoplasms

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency	IGF1 DEFICIENCY
Insulin-Like Growth Factor I, Resistance To	Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Growth Delay Due To Insulin-Like Growth Factor I Resistance
IGF1RES	Igf-I Resistance
Somatomedin, End-Organ Insensitivity To	Somatomedin-C
Somatomedin-C, Resistance To	Growth Retardation With Sensorineural Deafness And Mental Retardation
Insulin-Like Growth Factor 1 Resistance To	Igf-1 Resistance
Somatomedin End-Organ Insensitivity To	Somatomedin-C Resistance To
Growth Restriction With Sensorineural Deafness And Intellectual Disability	Growth Delay-Deafness-Intellectual Disability Syndrome
Growth Delay-Hearing Loss-Intellectual Disability Syndrome	Igf-1 Deficiency
Primary Insulin-Like Growth Factor Deficiency	Resistance To Igf-1
Insulin-Like Growth Factor 1 Resistance	End-Organ Insensitivity To Somatomedin
Igf1 Resistance	Resistance To Insulin-Like Growth Factor I
Resistance To Somatomedin-C	Insulin-Like Growth Factor 1, Resistance To

Pituitary Apoplexy

Pituitary Tumor Apoplexy

Hyperthyroidism

Overactive Thyroid

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Hypothyroidism, Congenital, Nongoitrous, 4

Tsh Deficiency	CHNG4
Thyrotropin Deficiency, Isolated	Pituitary Cretinism
Congenital Nongoitrous Hypothyroidism 4	Isolated Thyrotropin Deficiency
Thyroid-Stimulating Hormone Deficiency	Hypothyroidism, Congenital, Nongoitrous 4
Thyroid-Stimulating Hormone, Deficiency Of	Isolated Thyroid-Stimulating Hormone Deficiency
Isolated Tsh Deficiency	Hypothyroidism, Congenital, Nongoitrous, Type 4
Secondary Hypothyroidism	Tsh - [Thyroid Stimulating Hormone] Deficiency

Central Diabetes Insipidus

Neurogenic Diabetes Insipidus	Diabetes Insipidus Cranial Type
Diabetes Insipidus Neurogenic	Diabetes Insipidus Neurohypophyseal
Neurohypophyseal Diabetes Insipidus	Pituitary Diabetes Insipidus
Cdi	Doid:0081055
Diabetes Insipidus	Di - [Diabetes Insipidus]
Adh - [Antidiuretic Hormone Secretion] Deficiency	Diabetes Mellitus Insipidus
Familial Diabetes Insipidus	Antidiuretic Hormone Hyposecretion
Vasopressin Deficiency Syndrome	Primary Central Diabetes Insipidus
Vasopressin Deficiency	Vasopressin Hyposecretion
Diabetes Insipidus Secondary To Vasopressin Deficiency

Marasmus

Nutritional Marasmus

Nutritional Atrophy

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Protein-Deficiency Anemia

Anemia Due To Protein Deficiency	Protein-Deficiency Anaemia
Amino-Acid Deficiency Anaemia	Anaemia Due To Amino-Acid Disorder

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Hyperinsulinism

Hyperinsulinemia

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Premature Ovarian Failure 7

Adrenocortical Insufficiency	POF7
Adrenal Insufficiency, Nr5a1-Related	AINR
Ovarian Failure, Premature, Type 7	Hypoaldosteronism
Adrenal Cortical Hypofunction	Adrenal Failure Nos
Hypoadrenocorticism	Adrenocortical Hypofunction
Adrenal Cortex Hypofunction	Adrenal Cortex Deficiency
Adrenal Gland Insufficiency	Adrenal Hypofunction
Adrenal Insufficiency	Suprarenal Insufficiency
Corticoadrenal Insufficiency Nos	Corticoadrenal Hypofunction
Corticoadrenal Deficiency	Hypoadrenia
Hypoadrenalism	Aldosterone Deficiency

Uremia

Uremia Of Renal Origin

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Hyperandrogenism

Hyperandrogenization Syndrome

Hypogonadism

Acanthosis Nigricans

Keratosis Nigricans

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Syringomyelia

Hydromyelia

Vipoma

Wdha Syndrome	Pancreatic Cholera
Pancreatic Vipoma	Verner-Morrison Syndrome
Diarrheogenic Islet Cell Tumor	Vip-Secreting Tumor
Malignant Vasoactive Intestinal Peptide-Secreting Tumor	Vasoactive Intestinal Peptide-Secreting Tumor
Vip- Secreting Tumor	Vipoma, Malignant
Vipoma Syndrome	Watery Diarrhea Syndrome
Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome	Vasoactive Intestinal Peptide Tumor
Vasoactive Intestinal Peptide-Producing Tumor	Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome
Malignant Vipoma

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Hyperpituitarism

Diabetes Insipidus

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Diencephalic Astrocytoma

Astrocytoma Of Diencephalon

Hyperglycemia

Pituitary Adenoma 1, Multiple Types

Pituitary Adenoma Predisposition	PITA1
Isolated Familial Somatotropinoma	Fis
Ifs	Somatotrophinoma, Familial
Acromegaly Due To Pituitary Adenoma 1	Pagh1
Pituitary Adenoma 1	Somatotropinoma, Familial Isolated
Somatotropic Adenoma	Somatotropinoma
Pituitary Gigantism	Hypophyseal Gigantism
Infantile And Juvenile Forms Of Acromegaly	Acromegaly Due To Pituitary Adenoma
Familial Isolated Pituitary Adenoma	Familial Isolated Somatotropinomas
Familial Somatotrophinoma	Fipa
Pituitary Adenoma, Growth Hormone-Secreting, 1	Gigantism Pituitary
Pituitary Adenoma, Type 1, Multiple Types	Gigantism
Pituitary Adenoma, Familial Isolated	Multiple Gastrointestinal Atresias

Pituitary-Dependent Cushing'S Disease

Pituitary-Dependent Cushing Disease	Pituitary Acth Hypersecretion
Overproduction Of Acth	Pituitary-Dependent Cushings Disease
Overproduction Of Pituitary Acth	Pituitary-Dependent Hyperadrenocorticism
Corticotroph Pituitary Adenoma	Acth- [Adrenocorticotropic Hormone] Secreting Pituitary Adenoma
Cushing Syndrome Or Disease, Pituitary-Dependent	Cushings Basophilism
Cushing'S Syndrome 3	Itsenko-Cushing Syndrome
Itsenko Disease	Pituitary Basophilism
Pituitary-Dependent Hypercorticalism	Suprarenogenic Syndrome
Cushing Disease	Cushing'S Disease

Craniopharyngioma

Neoplasm Of Rathke'S Pouch	Adamantinomatous Tumor
Craniopharyngeal Duct Tumor	Dysodontogenic Epithelial Tumor
Rathke'S Pouch Tumor

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Adermatoglyphia

ADERM	Immigration Delay Disease
Absence Of Fingerprints	Adg
Congenital Absence Of Fingerprints	Isolated Congenital Adermatoglyphia
Fingerprints, Absence Of	Skin Abnormalities

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism	Hyperparathyroidism, Primary
Hyperparathyroidism Primary	Hypocalciuric Hypercalcemia, Familial, Type 1
Familial Benign Hypercalcemia	Familial Hyperparathyroidism
Parathyroid Enlargement

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Nickel Allergic Contact Dermatitis

Allergic Contact Dermatitis To Ni

Sheehan Syndrome

Postpartum Hypopituitarism	Sheehan'S Syndrome
Postpartum Panhypopituitarism	Postpartum Panhypopituitary Syndrome
Postpartum Pituitary Necrosis	Simmond'S Disease

Diabetes Mellitus

Diabetes

Nutritional Deficiency Disease

Malnutrition	Nutritional Disorder
Nutritional Deficiency	Nutrition
Deficiency Diseases	Carbamoyl-Phosphate Synthase I Deficiency Disease
Nutrition Disorders

Proprotein Convertase 1/3 Deficiency

Obesity Due To Prohormone Convertase I Deficiency	Obesity With Impaired Prohormone Processing
Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones	Pci Deficiency
Proprotein Convertase 1 3 Deficiency	Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency
Proprotein Convertase 1 Deficiency	PC1 DEFICIENCY

Scoliosis

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Van Maldergem Syndrome 1

Cerebrofacioarticular Syndrome	VMLDS1
Van Maldergem Syndrome	Cerebro-Facio-Articular Syndrome
Van Maldergem Wetzburger Verloes Syndrome

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Partial Third-Nerve Palsy

Partial Third Nerve Palsy	Third Nerve Palsy With Pupil Sparing
Third Or Oculomotor Nerve Palsy, Partial	Oculomotor Nerve Diseases
Oculomotor Nerve Paralysis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency

17-Ksr Deficiency	Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency
Pseudohermaphroditism, Male, With Gynecomastia	17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency
Testosterone 17-Beta-Dehydrogenase Deficiency	17-Ketosteroid Reductase Deficiency Of Testis
17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency	17-Ketoreductase Deficiency
17-Ketosteroidreductase Deficiency	46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency
Male Pseudohermaphroditism With Gynecomastia	17 Alpha Ksr Deficiency
17 Alpha Ketosteroid Reductase Deficiency Of Testis	17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency
Male Pseudoherma-Phroditism With Gynecomastia	Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency
Male Pseudohermaphrodism With Gynecomastia	MPH
17-Hydroxysteroid Dehydrogenase Deficiency

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1515	FM1-84		98.92%	Unkown
HY-RS05408	GH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GH1	RGD	RGD:2686
Mus musculus	GH1	MGD	MGI:95707