glycoprotein C/gC Protein, HHV-2 (Cell-Free, His)

Glycoprotein C (gC protein) is an important attachment protein that promotes virus binding to the cell surface by interacting with heparan sulfate or chondroitin sulfate. This critical role emphasizes its importance during the initial stages of viral infection. glycoprotein C/gC Protein, HHV-2 (Cell-Free, His) is the recombinant Virus-derived glycoprotein C/gC protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of glycoprotein C/gC Protein, HHV-2 (Cell-Free, His) is 453 a.a., with molecular weight of 50.5 kDa.

Glycoprotein C (gC Protein) emerges as a crucial attachment protein facilitating virus binding to cell surfaces through interactions with heparan sulfate or chondroitin sulfate. This pivotal role underscores its significance in the initial stages of viral infection. Beyond its attachment function, gC Protein also plays a vital role in immune evasion by inhibiting the activation of the host complement cascade. Its interaction with host complement component C3b leads to the modulation of the complement cascade, disrupting the host immune response. This dual functionality positions gC Protein as a key player in both the viral entry process and the virus's evasion of the host immune system.

Virus

E. coli Cell-free

N-10*His

Q89730 (S28-R480)

1487331

SPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATKSKASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTEFRLQIWRYATATDAEIGTAPSLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSVVGPLGRQRLIIEELTLETQGMYYWVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDPAQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTGDHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGIPVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAVVLAGTAVVYLTHASSVRYRRLR

50.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.