GNAO1 Protein, Mouse (His)

GNAO1 protein is a member of G proteins and plays a vital role in regulating or transducing signals in a variety of transmembrane signaling systems, but the specific function of G(o) proteins remains unclear. G proteins have three units—alpha, beta, and gamma—that mediate cellular responses. GNAO1 Protein, Mouse (His) is the recombinant mouse-derived GNAO1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GNAO1 Protein, Mouse (His) is 353 a.a., with molecular weight of ~44 kDa.

GNAO1, a member of guanine nucleotide-binding proteins (G proteins), serves as a crucial modulator or transducer in diverse transmembrane signaling systems, although the specific function of the G(o) protein remains unclear. Comprising three units—alpha, beta, and gamma—G proteins play an essential role in mediating cellular responses to extracellular signals. The alpha chain of GNAO1 hosts the guanine nucleotide binding site, a key element in its regulatory activity. GNAO1 forms a complex with GNB1 and GNG3, highlighting the intricate interplay within the G protein structure. Furthermore, GNAO1 is stimulated by RGS14 and interacts with regulatory proteins like RGS19, further elucidating its involvement in finely tuned signal modulation.

Mouse

E. coli

N-6*His

P18872 (G2-Y354)

14681  [NCBI]

GCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Approximately 44 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.