HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His)

Hemagglutinin esterase is a structural protein with a short spike that is critical for viral attachment and initiation of infection. It exhibits receptor binding and destructive activities, de-O-acetylating possible viral receptor determinants. HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His) is the recombinant bovine-derived HE/Hemagglutinin-esterase, expressed by P. pastoris , with N-His labeled tag. The total length of HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His) is 406 a.a.,

Hemagglutinin-esterase is a structural protein characterized by short spikes on the virus surface, playing a crucial role in viral attachment and infection initiation. This multifunctional protein exhibits both receptor binding and receptor-destroying activities, specifically mediating the de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, a probable receptor determinant recognized by the virus on erythrocytes and susceptible cells. The receptor-destroying activity is vital for facilitating virus release, preventing self-aggregation, and ensuring efficient progeny virus spread between cells. Serving as a secondary viral attachment protein, complementing the primary spike protein, it may become a target for immune responses, both humoral and cellular, contributing to the host defense against viral infections.

Bovine

P. pastoris

N-His

P15776 (F19-A424)

/

FDNPPTNVVSHLNGDWFLFGDSRSDCNHVVNTNPRNYSYMDLNPALCDSGKISSKAGNSIFRSFHFTDFYNYTGEGQQIIFYEGVNFTPYHAFKCTTSGSNDIWMQNKGLFYTQVYKNMAVYRSLTFVNVPYVYNGSAQSTALCKSGSLVLNNPAYIAREANFGDYYYKVEADFYLSGCDEYIVPLCIFNGKFLSNTKYYDDSQYYFNKDTGVIYGLNSTETITTGFDFNCHYLVLPSGNYLAISNELLLTVPTKAICLNKRKDFTPVQVVDSRWNNARQSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYDSPCFSQQGVFRYDNVSSVWPLYSYGRCPTAADINTPDVPICVYDPLPLILLGILLGVAVIIIVVLLLYFMVDNGTRLHDA

Approximately 47.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.