HA/Hemagglutinin Protein, Influenza B (EPI529345, sf9)

HA/Hemagglutinin proteins are Class I fusion proteins with multiple functions as attachment factors and membrane fusion proteins. HA/Hemagglutinin proteins can bind to cell surface receptors containing sialic acid, promote the attachment of virus particles to host cells, and play an important role in viral host range limitation and virulence. HA/Hemagglutinin Protein, Influenza B (EPI529345, sf9) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with tag free.

Hemagglutinin is a Class I fusion protein, which has multiple functions as an attachment factor and membrane fusion protein, and plays a crucial role in the viral life cycle. It binds to cell surface receptors containing sialic acid, promoting the attachment of viral particles to host cells. This attachment leads to internalization of virions through clathrin-dependent endocytosis pathways or pathways independent of clathrin and poretin. Hyaluronic acid protein is a kind of viral fusion protein, which is responsible for mediating the fusion of endocytotic virus particle membrane and endosomal membrane. This fusion event allows the virus to enter the cytoplasm of the cell. The low pH environment of the endosome triggers irreversible conformational changes in the protein HA2 subunit, resulting in the release of fusion hydrophobic peptides. Multiple trimers of HA proteins are necessary to form a qualified fusion pore. The function of hyaluronic acid protein in receptor binding, viral internalization, fusion, and membrane penetration is critical in determining viral host range limitation and virulence. Influenza hemagglutinin (HA) is a homologous trimer glycoprotein found on the surface of influenza virus and is an integral part of its infectivity^[1][2][3].

Virus

Sf9 insect cells

Tag Free

EPI529345.1 (D16-L584)

/

Approximately 61.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.