2. Recombinant Proteins
  3. Viral Proteins
  4. Influenza Viruses Proteins
  5. Influenza Hemagglutinin
  6. HA1/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His)

HA1/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His)

Cat. No.: HY-P76443
Handling Instructions

HA/Hemagglutinin Protein is a type of viral fusion protein. It mediates the fusion of the membrane of endocytosed virus particles with the endosomal membrane, responsible for the penetration of the virus into the cytoplasm. HA/Hemagglutinin Protein binds to sialic acid receptors, allowing the virus particles to attach to cells. HA/Hemagglutinin Protein is a homotrimer consisting of a globular head domain located at the top of the stem domain near the membrane. HA1/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

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Description

HA/Hemagglutinin Protein is a type of viral fusion protein. It mediates the fusion of the membrane of endocytosed virus particles with the endosomal membrane, responsible for the penetration of the virus into the cytoplasm. HA/Hemagglutinin Protein binds to sialic acid receptors, allowing the virus particles to attach to cells. HA/Hemagglutinin Protein is a homotrimer consisting of a globular head domain located at the top of the stem domain near the membrane. HA1/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.
Background

HA/Hemagglutinin Protein is a type of viral fusion protein that mediates the fusion of the membrane of endocytosed virus particles with the endosome membrane, responsible for penetrating the virus into the cytoplasm. The membrane fusion mediated by HA/Hemagglutinin Protein occurs in vivo and depends on the pH value in vivo. The acidic environment in vivo triggers conformational changes in HA/Hemagglutinin Protein, which in turn induces virus-host membrane fusion. HA/Hemagglutinin Protein binds to sialic acid receptors, allowing the virus particles to attach to cells. HA/Hemagglutinin Protein is a homotrimer consisting of a globular head domain located at the top of the membrane proximal stalk domain[1][2].
Species

Virus
Source

HEK293
Tag

C-His
Accession

AAY85533 (D17-R342)
Gene ID

/
Molecular Construction
N-term
HA1/Hemagglutinin (D17-R342)
Accession # AAY85533
His
C-term
Synonyms
Influenza A H11N2 (A/duck/Yangzhou/906/2002) Hemagglutinin Protein (HA1 Subunit) (His)
Molecular Weight

45-50 kDa.
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

HA1/Hemagglutinin Protein, H11N2 (AAY85533, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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