NS3 protease Protein, HCV (GST)

NS3 protease Protein is a zinc-dependent serine protease.NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization.NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity.NS3 protease Protein, HCV (GST) is the recombinant Virus-derived NS3 protease protein, expressed by E.coli , with N-GST labeled tag.

Non-structural protein 3 (NS3), also known as p-70, is the cleavage product of hepatitis C virus polyprotein 70 kDa. It is a zinc-dependent serine protease. Two-thirds of the C-terminal also acts as helicase and nucleoside triphosphatase. NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity. NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization^[1][2][3][4].

Virus

E. coli

N-GST

NP_803144 (T1356-T1459)

/

Approximately 37.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.