HHLA2 Protein, Human (HEK293, His)

HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (HEK293, His) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of HHLA2 Protein, Human (HEK293, His) is 322 a.a., with molecular weight of ~38.4 KDa.

The HHLA2 protein, a pivotal player in immune regulation, engages in a significant interaction with TMIGD2 to provide costimulation to T-cells during T-cell receptor (TCR)-mediated activation. This interaction, in turn, amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade. The collaboration between HHLA2 and TMIGD2 underscores the intricate molecular mechanisms involved in enhancing T-cell responses, shedding light on its role in immune modulation.

Human

HEK293

C-His

Q9UM44/NP_009003.1 (I23-N344)

11148  [NCBI]

Approximately 38.4 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.