HLA-C*0304 KRAS G12D Complex Protein, Human (GADGVGKSAL, HEK293, His-Avi)

The HLA-C*0304 KRAS G12D complex is a major histocompatibility complex class I (MHCI) molecule that plays a crucial role in reproduction and antiviral immunity. It collaborates with B2M to present self- and viral peptides as primary ligands that inhibit and activate killer immunoglobulin receptors (KIRs) on NK cells. HLA-C*0304 KRAS G12D Complex Protein, Human (GADGVGKSAL, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-C*0304 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and GADGVGKSAL peptide. HLA-C*0304 KRAS G12D Complex Protein, Human (GADGVGKSAL, HEK293, His-Avi), has molecular weight of 55-65 kDa.

HLA-C*0304, an antigen-presenting major histocompatibility complex class I (MHCI) molecule, plays a pivotal role in reproduction and antiviral immunity. In association with B2M/beta 2 microglobulin, it exhibits a specific range of self and viral peptides, serving as a dominant ligand for both inhibitory and activating killer immunoglobulin receptors (KIRs) on NK cells. Particularly crucial in an allogeneic context, such as during pregnancy, HLA-C*0304 facilitates the interaction between extravillous trophoblasts and uterine NK cells expressing KIRs, regulating trophoblast invasion essential for placentation and overall fetal growth. During viral infections, HLA-C*0304 may present viral peptides with low affinity for KIRs, disrupting KIR-mediated inhibition through peptide antagonism and promoting the lysis of infected cells. In the realm of adaptive immunity, HLA-C*0304 presents a restricted repertoire of viral peptides to CD8-positive T cells, enabling antigen-specific T cell immune responses against infected cells, particularly in chronic viral infections like HIV-1 or CMV. The binding of peptides with allele-specific motifs, defined by anchor residues at positions 2 and 9, showcases HLA-C*0304's ability to recognize diverse peptide antigens arising from cytosolic proteolysis via the proteasome. The peptide's fine specificity for antigen recognition and MHC residues accounting for T cell MHC restriction collectively contribute to HLA-C*0304's role in immune surveillance.

Human

HEK293

C-Avi;C-His

QAV56463.1 (G25-T305)&P61769 (I21-M119)&GADGVGKSAL

/&567

55-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.