HOXA1 Protein, Human (His)

The HOXA1 protein is a sequence-specific transcription factor that complexly regulates multiple developmental processes in the brainstem, inner and outer ears, abducens nerves, and cardiovascular development. It also plays a key role in cognitive and behavioral processes. HOXA1 Protein, Human (His) is the recombinant human-derived HOXA1 protein, expressed by E. coli , with N-His labeled tag.

HOXA1 protein functions as a sequence-specific transcription factor, intricately regulating diverse developmental processes encompassing the brainstem, inner and outer ear, abducens nerve, and cardiovascular development. Additionally, it plays a pivotal role in cognitive and behavioral processes. Integral to a developmental regulatory system that imparts specific positional identities along the anterior-posterior axis, HOXA1 primarily influences anterior body structures and contributes to the maintenance or generation of hindbrain segments. Its transcriptional activation is contingent upon the presence of PBX1A and PKNOX1. In the nucleus, HOXA1 interacts with OGT via the TPR repeats domain. Furthermore, it forms a DNA-binding heterodimer with the transcription factor PBX1, highlighting its multifaceted role in orchestrating intricate developmental programs.

Human

E. coli

N-His

P49639-1 (M1-H335)

3198  [NCBI]

Approximately 42 kDa

Greater than 85% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.22 μm filtered solution in 50 mM Tris, 30% Glycerol, pH 7.5 or 20 mM MES, 1 M Urea, 300 mM NaCl, 1 mM DTT, pH 6.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.