HCMV Glycoprotein B/gB Protein (HEK293)

The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (HEK293) is a recombinant Virus-derived HCMV Glycoprotein B/gB protein(with cleavage site mutated RTKR to TTQT), expressed by HEK293 , with tag free. HCMV Glycoprotein B/gB Protein (HEK293), has molecular weight of 130-140 kDa.

gB is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB is involved in initial attachment through a gM/gN complex bound to heparin sulfate, which binds heparin with higher affinity. gB plays a key role in the fusion of viruses and cell membranes, facilitating the entry of viruses into host cells. The complex fusion mechanisms required for this process include at least gB and gH/gL heterodimers. gB interacts with host integrins ITGB1, PDGFRA, and EGFR, possibly entering the receptor as post-attachment^[1][2][3].

Virus

HEK293

Tag Free

AAA45920 (S25-K700&R777-V907, with cleavage site mutated RTKR to TTQT)

/

130-140 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.