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  3. HCMV Glycoprotein B/gB Protein (HEK293)

HCMV Glycoprotein B/gB Protein (HEK293)

Cat. No.: HY-P74875
Handling Instructions

The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (HEK293) is a recombinant Virus-derived HCMV Glycoprotein B/gB protein(with cleavage site mutated RTKR to TTQT), expressed by HEK293 , with tag free. HCMV Glycoprotein B/gB Protein (HEK293), has molecular weight of 130-140 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

The gB Protein is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB Protein interacts with heparin sulfate proteoglycan and forms an association with gH/gL heterodimer. HCMV Glycoprotein B/gB Protein (HEK293) is a recombinant Virus-derived HCMV Glycoprotein B/gB protein(with cleavage site mutated RTKR to TTQT), expressed by HEK293 , with tag free. HCMV Glycoprotein B/gB Protein (HEK293), has molecular weight of 130-140 kDa.

Background

gB is an envelope glycoprotein that plays a role in host cell entry, cell-to-cell viral transmission, and infected cell fusion. gB is involved in initial attachment through a gM/gN complex bound to heparin sulfate, which binds heparin with higher affinity. gB plays a key role in the fusion of viruses and cell membranes, facilitating the entry of viruses into host cells. The complex fusion mechanisms required for this process include at least gB and gH/gL heterodimers. gB interacts with host integrins ITGB1, PDGFRA, and EGFR, possibly entering the receptor as post-attachment[1][2][3].

Species

Virus

Source

HEK293

Tag

Tag Free

Accession

AAA45920 (S25-K700&R777-V907, with cleavage site mutated RTKR to TTQT)

Gene ID

/

Synonyms
Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein
Molecular Weight

130-140 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

HCMV Glycoprotein B/gB Protein (HEK293) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
HCMV Glycoprotein B/gB Protein (HEK293)
Cat. No.:
HY-P74875
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