IGFBP-5 Protein, Human (sf9, His)

The IGFBP-5 protein regulates insulin-like growth factor (IGF) and extends its lifespan. It can inhibit or stimulate the growth-promoting effect of IGF, showing its dual regulatory function. IGFBP-5 Protein, Human (sf9, His) is the recombinant human-derived IGFBP-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

IGFBP-5 protein assumes a crucial role in regulating the activity of insulin-like growth factors (IGFs) by extending their half-life. Within cell culture, IGFBP-5 has demonstrated the ability to either inhibit or stimulate the growth-promoting effects of IGFs. This dual regulatory function underscores the complexity of IGFBP-5's influence on cellular processes. Importantly, IGFBP-5 achieves these effects by modulating the interaction between IGFs and their cell surface receptors, thereby fine-tuning the signaling pathways associated with growth and development. The intricate interplay between IGFBP-5 and IGFs highlights the nuanced control mechanisms that govern cellular responses to growth factors, offering insights into the multifaceted role of IGFBP-5 in the regulation of cellular growth and proliferation.

Human

Sf9 insect cells

C-His

P24593/NP_000590.1 (L21-E272)

3488  [NCBI]

Approximately 30 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.