2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-19
  6. IL-19 Protein, Human (HEK293, His)

IL-19 Protein, Human (HEK293, His)

Cat. No.: HY-P73184
Handling Instructions

IL-19 protein acts as an anti-inflammatory and pro-angiogenic cytokine. IL-19 Protein, Human (HEK293, His) is the recombinant human-derived IL-19 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

IL-19 protein acts as an anti-inflammatory and pro-angiogenic cytokine. IL-19 Protein, Human (HEK293, His) is the recombinant human-derived IL-19 protein, expressed by HEK293 , with C-His labeled tag.
Background

The IL-19 Protein serves a dual role as an anti-inflammatory and proangiogenic factor. It plays a crucial role in shaping adaptive immunity towards an anti-inflammatory phenotype by inducing T-helper 2 responses, achieved through the down-regulation of IFN-gamma and the up-regulation of IL4 and IL13. Produced by osteocytes, IL-19 also contributes to granulopoiesis and the formation of neutrophils. Its biological effects are mediated through a receptor complex comprising the IL20RA and IL20RB heterodimer. Upon binding, IL-19 activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, particularly emphasizing STAT3 activation, highlighting its pivotal role in diverse immunomodulatory functions.
Species

Human
Source

HEK293
Tag

C-His
Accession

Q9UHD0-1 (L25-A177)
Gene ID
Molecular Construction
N-term
IL-19 (L25-A177)
Accession # Q9UHD0-1
His
C-term
Synonyms
Interleukin-19; IL-19; IL19; ZMDA1
Molecular Weight

Approximately 19.2 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IL-19 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
IL-19 Protein, Human (HEK293, His)
Cat. No.:
HY-P73184
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.