IL-31 Protein, Mouse (HEK293, His)

IL-31 Protein activates STAT3, potentially STAT1 and STAT5, through the IL31 receptor. It enhances myeloid progenitor cell survival and induces RETNLA and serum amyloid A protein expression in macrophages. IL-31 Protein's diverse functions suggest its importance in biological processes and potential implications in immune regulation and cell survival. IL-31 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31 protein, expressed by HEK293 , with C-His labeled tag.

IL-31 Protein activates STAT3 and potentially STAT1 and STAT5 through the IL31 heterodimeric receptor, which consists of IL31RA and OSMR. It has been suggested to play a role in skin immunity and enhances the survival of myeloid progenitor cells in vitro. IL-31 Protein also induces the expression of RETNLA and serum amyloid A protein in macrophages. These diverse functions highlight the significance of IL-31 Protein in various biological processes and suggest its potential implications in immune regulation and cell survival.

Mouse

HEK293

C-His

Q6EAL8/NP_083870.1 (T24-C163)

76399  [NCBI]

Approximately 17.1 kDa

Greater than 85% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.