IL-31R alpha Protein, Mouse (HEK293, His)

The IL-31R alpha protein is critical to the immune response and forms the interleukin 31 receptor with OSMR. It activates STAT3, and to a lesser extent STAT1 and STAT5, is associated with skin immunity and mediates IL31-induced itch, possibly involving the cation channels TRPA1 and TRPV1. IL-31R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31R alpha protein, expressed by HEK293 , with a C-His labeled tag.

The IL-31R alpha protein plays a crucial role in immune response, as it forms the interleukin-31 receptor by associating with OSMR. This receptor activates STAT3, and to a lesser extent, STAT1 and STAT5. It is believed to be involved in skin immunity and mediates IL31-induced itch, potentially relying on cation channels TRPA1 and TRPV1. Additionally, IL-31R alpha positively regulates the numbers and cycling status of immature subsets of myeloid progenitor cells in the bone marrow, both in vivo and in vitro, enhancing myeloid progenitor cell survival. It forms a heterodimer with OSMR and interacts with JAK1 and STAT3.

Mouse

HEK293

C-His

Q8K5B1-1 (V19-T499)

218624  [NCBI]

80-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.