IL-5 Protein, Cynomolgus (sf9, His)

IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

IL-5 Protein is a homodimeric cytokine primarily produced by T-lymphocytes and NK cells, playing a crucial role in eosinophil survival, differentiation, and chemotaxis. It also acts on B-cells, stimulating immunoglobulin production, growth, and differentiation. IL-5 Protein exerts its effects through a receptor composed of IL5RA and CSF2RB subunits, leading to the activation of various kinases such as LYN, SYK, and JAK2. This activation propagates signals through the RAS-MAPK and JAK-STAT5 pathways. IL-5 Protein exists as a disulfide-linked homodimer.

Cynomolgus

Sf9 insect cells

C-His

A0A2K5U1E7 (I20-S134)

/

Approximately 14.6 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.