Integrin alpha L beta 2 Protein, Mouse (HEK293, His)

Integrin alpha L beta 2 Protein, a receptor for ICAM1, ICAM2, ICAM3, ICAM4, and F11R, participates in immune phenomena, including leukocyte-endothelial cell interaction, cytotoxic T-cell killing, and antibody-dependent killing. It contributes to natural killer cell cytotoxicity and leukocyte adhesion and transmigration. Essential for common lymphoid progenitor cell generation, indicating a role in lymphopoiesis. In association with ICAM3, it contributes to apoptotic neutrophil phagocytosis by macrophages. Interacts with THBD. Integrin alpha L beta 2 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha L beta 2 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha L beta 2 Protein, Mouse (HEK293, His), has molecular weight of 160-180 kDa (ITGAL) & 90-105 kDa (ITGB2), respectively.

Integrin alpha L beta 2 (ITGAL/ITGB2) serves as a receptor for ICAM1, ICAM2, ICAM3, and ICAM4, and also interacts with the secreted form of ubiquitin-like protein ISG15 through its ITGAL subunit. Additionally, it functions as a receptor for F11R and plays a role in immune processes such as leukocyte-endothelial cell interaction, cytotoxic T-cell-mediated killing, and antibody-dependent killing by granulocytes and monocytes. ITGAL/ITGB2 contributes to natural killer cell cytotoxicity, as well as leukocyte adhesion and transmigration, involving T-cells and neutrophils. Its significance extends to the generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Furthermore, in association with ICAM3, ITGAL/ITGB2 contributes to apoptotic neutrophil phagocytosis by macrophages. The heterodimeric structure comprises an alpha subunit (ITGAL) and a beta subunit (ITGB2), with the alpha subunit interacting with THBD. This multifaceted functionality underscores the diverse roles of Integrin alpha L beta 2 in various immune and cellular processes.

Mouse

HEK293

C-His

P24063-1 (Y24-H1087)&P11835 (Q24-N702)

/&16414

160-180 kDa(ITGAL) & 90-105 kDa(ITGB2)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.