ITGB6 Protein, Human (HEK293, His)

The ITGB6 protein forms integrin alpha-V:beta-6 (ITGAV:ITGB6), which acts as a receptor for fibronectin, chemokines, and fibrillin-1. It recognizes the RGD sequence in the ligand and promotes cancer cell invasion through clathrin-mediated endocytosis. ITGB6 Protein, Human (HEK293, His) is the recombinant human-derived ITGB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of ITGB6 Protein, Human (HEK293, His) is 686 a.a., with molecular weight of 80-115 kDa.

Integrin alpha-V:beta-6 (ITGAV:ITGB6) serves as a multifaceted receptor, recognizing the R-G-D sequence in its ligands such as fibronectin and cytotactin. Through clathrin-mediated endocytosis, internalization of integrin alpha-V/beta-6 facilitates carcinoma cell invasion. Furthermore, ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. This integrin duo also plays a pivotal role in the release of transforming growth factor beta-1 (TGF-beta-1) from the regulatory Latency-associated peptide (LAP), thereby contributing significantly to TGF-beta-1 activation. Notably, in the context of microbial infection, ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.

Human

HEK293

C-His

P18564-1 (G22-N707)

/

80-115 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.