1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Epithelial cell CD Proteins Endothelial cell CD Proteins Notch family
  4. Jagged-1/CD339
  5. Jagged-1/JAG1 Protein, Human (HEK293, Fc)

Jagged-1/JAG1 Protein, Human (HEK293, Fc)

Cat. No.: HY-P70399
Data Sheet SDS COA Handling Instructions

Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, Fc) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
10 μg USD 160 In-stock
50 μg USD 450 In-stock
100 μg   Get quote  

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  • Biological Activity

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Description

Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, Fc) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-hFc labeled tag.

Background

The Jagged-1 (JAG1) protein functions as a ligand for multiple Notch receptors, playing a crucial role in mediating Notch signaling, as evidenced by its interactions with NOTCH1, NOTCH2, and NOTCH3. Its involvement in cell-fate decisions during hematopoiesis suggests a regulatory role in blood cell development. JAG1 is implicated in various stages of mammalian cardiovascular development and has been associated with both early and late phases of this process. Additionally, it inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis in vitro. Notably, the interaction between JAG1 and NOTCH1 is calcium ion-dependent, highlighting the complexity of its regulatory mechanisms in cellular processes.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P78504-1 (Q34-S1046)

Gene ID

182  [NCBI]

Molecular Construction
N-term
JAG1 (Q34-S146)
Accession # P7854-1
hFc
C-term
Synonyms
rHuJagged-1/JAG1, Fc; Protein jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339
AA Sequence

QFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNS

Molecular Weight

140-200 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Documentation
  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Jagged-1/JAG1 Protein, Human (HEK293, Fc)
Cat. No.:
HY-P70399
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