JOSD1 Protein, Human (GST)

The JOSD1 protein is a versatile player in ubiquitin dynamics and exhibits deubiquitinase activity by cleaving monoubiquitinated probes in vitro. When ubiquitinated, JOSD1 can cleave “Lys-63”-linked and “Lys-48”-linked polyubiquitin chains in vitro, suggesting its potential for deubiquitination. JOSD1 Protein, Human (GST) is the recombinant human-derived JOSD1 protein, expressed by E. coli , with N-GST labeled tag. The total length of JOSD1 Protein, Human (GST) is 201 a.a., .

JOSD1 Protein, a versatile player in ubiquitin dynamics, exhibits deubiquitinase activity by cleaving monoubiquitinated probes in vitro. Moreover, when ubiquitinated itself, JOSD1 can cleave both 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains in vitro, suggesting a potential role as a deubiquitinating enzyme. Beyond its catalytic functions, JOSD1 is implicated in cellular processes, influencing macropinocytosis positively and concurrently suppressing clathrin- and caveolae-mediated endocytosis. Notably, JOSD1 appears to contribute to membrane dynamics and cell motility independently of its enzymatic activity, highlighting its multifaceted role in orchestrating cellular responses and homeostasis.

Human

E. coli

N-GST

Q15040 (S2-V202)

9929

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.