Kallikrein-4 Protein, Human (254a.a, HEK293, His)

Kallikrein-4 Protein is crucial in enamel formation, particularly during tooth maturation, playing a significant role in clearing enamel proteins and contributing to the structural patterning of the crystalline matrix. Its involvement underscores its importance in intricate tooth development processes, emphasizing its role in proper dental structure and function. Kallikrein-4 Protein, Human (254a.a, HEK293, His) is the recombinant human-derived Kallikrein-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-4 Protein, Human (254a.a, HEK293, His) is 254 a.a., with molecular weight of 30-35 kDa.

Kallikrein-4 Protein plays a significant role in enamel formation, particularly during the maturation stage of tooth development. It is essential for the clearance of enamel proteins and contributes to the normal structural patterning of the crystalline matrix. This underscores the protein's crucial involvement in the intricate processes underlying tooth development and enamel maturation, highlighting its importance for proper dental structure and function.

Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is >250 pmol/min/μg.
(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)

Human

HEK293

C-His

Q9Y5K2 (M1-S254)

9622  [NCBI]

30-35 kDa

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.