KBTBD7 Protein, Human (Sf9, His, Strep)

KBTBD7 is a component of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex and acts as a substrate linker to direct “Lys-48” ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor TIAM1. This precise ubiquitination enables KBTBD7 to effectively regulate RAC1 signaling, affecting key biological processes such as cytoskeletal organization, cell migration, and cell proliferation. KBTBD7 Protein, Human (Sf9, His, Strep) is the recombinant human-derived KBTBD7 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of KBTBD7 Protein, Human (Sf9, His, Strep) is 683 a.a., .

KBTBD7, a key constituent of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, serves as a substrate adapter with a pivotal role in orchestrating the 'Lys-48' ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor (GEF) TIAM1. Through precise control of this ubiquitination process, KBTBD7 effectively modulates RAC1 signal transduction and influences various downstream biological processes, including cytoskeletal organization, cell migration, and cell proliferation. The ubiquitination of TIAM1 is contingent on the presence of the membrane-associated protein GABARAP, suggesting a potential local regulation of the complex's activity. With a primary role in protein ubiquitination, KBTBD7 plays a crucial part in fine-tuning cellular signaling pathways and regulating key cellular functions.

Human

Sf9 insect cells

N-Strep;N-8*His

Q8WVZ9 (Q2-L684)

84078

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.