Kirrel1/NEPH1 Protein, Human (HEK293, Fc)

The Kirrel1/NEPH1 protein is essential for the normal function of the glomerular filtration barrier in the kidney, maintaining stable podocyte structure through finger-like foot processes and gap septal cell-cell junctions. As a signaling molecule, it requires TEC kinase to fully activate the transcription factor AP-1. Kirrel1/NEPH1 Protein, Human (HEK293, Fc) is the recombinant human-derived Kirrel1/NEPH1 protein, expressed by HEK293 , with C-hFc labeled tag.

Kirrel1/NEPH1 Protein is crucial for the proper function of the glomerular filtration barrier in the kidneys. It plays a vital role in maintaining a stable podocyte architecture by facilitating the interdigitating foot processes connected by specialized cell-cell junctions called the slit diaphragm. This protein acts as a signaling molecule and requires the presence of TEC kinases to fully activate the transcription factor AP-1. Kirrel1/NEPH1 interacts with TJP1/ZO-1 and NPHS2/podocin, and its interaction with NPHS1/nephrin relies on Kirrel1/NEPH1 glycosylation. It forms homodimers through its Ig-like domains and, when tyrosine-phosphorylated, it interacts with GRB2.

Human

HEK293

C-hFc

Q96J84-1 (Q17-L493)

55243  [NCBI]

Approximately 96.1 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.