Kremen-2 Protein, Cynomolgus (HEK293, His)

Kremen-2 protein is a receptor for Dickkopf protein and cooperates with DKK1/2 to inhibit Wnt/β-catenin signaling by promoting LRP5 and LRP6 endocytosis. Its role in limb development ensures correct patterning and negatively affects bone formation. Kremen-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Kremen-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kremen-2 Protein, Cynomolgus (HEK293, His) is 339 a.a., with molecular weight of 50-65 kDa.

Kremen-2, functioning as a receptor for Dickkopf proteins, operates in collaboration with DKK1/2 to restrain Wnt/beta-catenin signaling by facilitating the endocytosis of Wnt receptors LRP5 and LRP6. This regulatory role extends to limb development, where Kremen-2 acts to attenuate Wnt signaling, ensuring the normal patterning of limbs and exerting a negative influence on bone formation. Additionally, Kremen-2 forms a ternary complex with DKK1 and LRP6, emphasizing its involvement in intricate molecular interactions crucial for modulating key signaling pathways. The interaction with ERLEC1 further underscores the multifaceted regulatory functions of Kremen-2 in cellular processes.

Cynomolgus

HEK293

C-His

XP_005591068.2 (G26-A364)

102136316  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.