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  3. Enzymes & Regulators
  4. Hydrolases (EC 3)
  5. KYNU/Kynureninase Protein, Mouse (sf9, His)

KYNU/Kynureninase Protein, Mouse (sf9, His)

Cat. No.: HY-P75904
Handling Instructions

KYNU, also known as Kynureninase protein, catalyzes the conversion of L-kynurenine and L-3-hydroxykynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively. It displays a preference for the L-3-hydroxy form and possesses cysteine-conjugate-beta-lyase activity as well. KYNU/Kynureninase Protein, Mouse (sf9, His) is the recombinant mouse-derived KYNU/Kynureninase protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of KYNU/Kynureninase Protein, Mouse (sf9, His) is 464 a.a., with molecular weight of ~47 kDa.

For research use only. We do not sell to patients.

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Description

KYNU, also known as Kynureninase protein, catalyzes the conversion of L-kynurenine and L-3-hydroxykynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively. It displays a preference for the L-3-hydroxy form and possesses cysteine-conjugate-beta-lyase activity as well. KYNU/Kynureninase Protein, Mouse (sf9, His) is the recombinant mouse-derived KYNU/Kynureninase protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of KYNU/Kynureninase Protein, Mouse (sf9, His) is 464 a.a., with molecular weight of ~47 kDa.
Background

The KYNU protein, known as Kynureninase, plays a pivotal role in the breakdown of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn), converting them into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA) correspondingly. It exhibits a specific affinity for the L-3-hydroxy form and possesses additional cysteine-conjugate-beta-lyase activity.
Species

Mouse
Source

Sf9 insect cells
Tag

C-His
Accession

Q9CXF0 (M1-S464)
Gene ID
Molecular Construction
N-term
KYNU (M1-S464)
Accession # Q9CXF0
His
C-term
Synonyms
Kynureninase; L-kynurenine hydrolase; KYNU
Molecular Weight

Approximately 47 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

KYNU/Kynureninase Protein, Mouse (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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