LRRN3/NLRR-3 Protein, Human (sf9, His)

Neuronal leucine-rich repeat protein-3 (NLRR-3), also known as LRRN3, potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles. NLRR-3 also regulates cellular differentiation^[1][2]. LRRN3/NLRR-3 Protein, Human (sf9, His) is the recombinant human-derived LRRN3/NLRR-3 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of LRRN3/NLRR-3 Protein, Human (sf9, His) is 628 a.a., with molecular weight of ~70 kDa.

Neuronal leucine-rich repeat protein-3 (NLRR-3), belongs to the LRR superfamily. NLRR-3 enhances phosphorylation of MAPK when COS-7 cells is transfected with NLRR-3. Mouse NLRR-3 also potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles^[1]. NLRR-3 is associated with the regulation of cellular differentiation^[1]. In addition, LRRN3 is a marker of naïve T.
Human NLRR-3 shares about 87% aa sequence identity with mouse and rat. Rat NLRR-3 shares about 95% aa sequence identity with mouse.

Human

Sf9 insect cells

C-His

Q9H3W5 (M1-T628)

54674  [NCBI]

Approximately 70 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.