LRRTM4 Protein, Human (HEK293, His)

The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.

LRRTM4 protein emerges as a key player in the development and maintenance of the vertebrate nervous system, with a particularly pronounced role in synaptogenesis, specifically influencing excitatory presynaptic differentiation. Functionally associated with the AMPA receptor (AMPAR) complex, LRRTM4 is positioned peripherally within this complex, which consists of an inner core comprising four pore-forming GluA/GRIA proteins and four major auxiliary subunits. LRRTM4 is part of the outer core, interacting directly with GluA/GRIA proteins, and contributes to the intricate network of proteins orchestrating AMPAR complex assembly and function. Understanding LRRTM4's role in the context of excitatory neurotransmission and the regulation of AMPAR complex dynamics holds promise for unraveling the complexities of synaptic connectivity in the nervous system. Further investigation is needed to elucidate the specific mechanisms by which LRRTM4 influences excitatory presynaptic differentiation and contributes to overall neural network development.

Human

HEK293

C-His

Q86VH4-1 (Q31-K424)

80059  [NCBI]

Approximately 65 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.