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Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P74441
COA Handling Instructions

Lymphocyte antigen 86/MD-1 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production.It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers.Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
5 μg $62 In-stock
10 μg $100 In-stock
50 μg $250 In-stock
100 μg $380 In-stock
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Description

Lymphocyte antigen 86/MD-1 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production.It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers.Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293 , with C-His labeled tag.

Background

The Lymphocyte antigen 86/MD-1 protein emerges as a potential collaborator with CD180 and TLR4, mediating the innate immune response to bacterial lipopolysaccharide (LPS) and influencing cytokine production. Additionally, Lymphocyte antigen 86/MD-1 plays a crucial role in facilitating efficient CD180 cell surface expression. The structural arrangement involves the formation of an M-shaped tetramer, comprising two CD180-LY86 heterodimers. These characteristics underscore the multifaceted nature of Lymphocyte antigen 86/MD-1 in orchestrating immune responses and cellular interactions. Further exploration is essential to unravel the specific molecular mechanisms through which Lymphocyte antigen 86/MD-1 contributes to the intricate dynamics of the innate immune system and its collaboration with CD180 and TLR4 in response to bacterial LPS.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

O88188 (M1-S162)

Gene ID
Molecular Construction
N-term
Ly86 (M1-S162)
Accession # O88188
His
C-term
Synonyms
LY86; lymphocyte antigen 86; MD-1; MMD-1; RP105-associated
Molecular Weight

24-30 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His)
Cat. No.:
HY-P74441
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