MAGEA4 Protein, Human (HEK293, His)

MAGEA4 protein critically regulates cell proliferation by inhibiting G1 phase arrest and negatively modulates p53-mediated apoptosis. Its role in controlling key checkpoints emphasizes its impact on cellular homeostasis, suggesting significance in averting aberrant cell growth. MAGEA4 Protein, Human (HEK293, His) is the recombinant human-derived MAGEA4 protein, expressed by HEK293, with C-10*His labeled tag. The total length of MAGEA4 Protein, Human (HEK293, His) is 317 a.a., with molecular weight of 36.7 kDa.

The MAGEA4 protein plays a crucial role in regulating cell proliferation by inhibiting cell cycle arrest at the G1 phase, as evidenced by studies. Additionally, MAGEA4 exerts a negative regulatory effect on p53-mediated apoptosis, further highlighting its involvement in controlling cellular processes associated with cell cycle progression and apoptotic pathways. These functions underscore the significance of MAGEA4 in modulating key checkpoints that govern cell division and apoptosis, suggesting its potential impact on cellular homeostasis and the avoidance of aberrant cell growth.

Human

HEK293

C-10*His

P43358 (M1-V317)

4103  [NCBI]

MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV

36.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.