MAPKAPK2 Protein, Human

The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human is the recombinant human-derived MAPKAPK2 protein, expressed by E. coli , with tag free. and ΔH217-P237, S216G, , , mutation. The total length of MAPKAPK2 Protein, Human is 318 a.a., .

MAPKAPK2 protein is a stress-activated serine/threonine-protein kinase with a multifaceted role in cellular processes. It participates in cytokine production, endocytosis, cytoskeleton reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. Upon stress, MAPKAPK2 is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to the phosphorylation of various substrates. It phosphorylates serine in specific peptide sequences and targets proteins involved in diverse cellular functions. Notably, MAPKAPK2 mediates the inflammatory response by regulating the post-transcriptional aspects of tumor necrosis factor (TNF) and IL6 production. It accomplishes this by phosphorylating AU-rich element (ARE)-binding proteins, affecting mRNA stability and translation. Additionally, MAPKAPK2 plays a crucial role in the late G2/M checkpoint following DNA damage, contributing to post-transcriptional mRNA stabilization. Its involvement in the toll-like receptor signaling pathway in dendritic cells underscores its significance in immune responses. Overall, MAPKAPK2 emerges as a key player in orchestrating cellular responses to stress and various signaling pathways.

Human

E. coli

Tag Free

P49137-1 (H47-R364, ΔH217-P237, S216G)

9261

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.