MKNK1 Protein, Human (Sf9, GST)

MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) plays a central role in coordinating cellular responses to environmental stress and cytokines. It exerts regulatory control over translation processes by phosphorylating EIF4E, enhancing its affinity for mRNA cap structures with 7-methylguanosine. This highlights MKNK1's crucial involvement in finely tuning translation machinery in response to diverse cellular stimuli. MKNK1 Protein, Human (Sf9, GST) is the recombinant human-derived MKNK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MKNK1 Protein, Human (Sf9, GST) is 424 a.a., .

MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) emerges as a pivotal player in orchestrating cellular responses to environmental stress and cytokines. Its regulatory influence extends to translation processes, where it exerts control by phosphorylating EIF4E. This phosphorylation event enhances the affinity of EIF4E for the 7-methylguanosine-containing mRNA cap, elucidating MKNK1's role in fine-tuning translation machinery in response to diverse cellular stimuli.

Human

Sf9 insect cells

N-GST

Q9BUB5 (M1-L424)

8569

Approximately 73.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 150 mM NaCl, 10% glycerol, 0.05% Brij, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.