MRCKβ Protein, Human (sf9, GST)

CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells , with GST labeled tag. ,

CDC42BPB Protein, a serine/threonine-protein kinase, stands as a pivotal downstream effector of CDC42, exerting significant influence over cytoskeleton reorganization and cell migration. Through the phosphorylation of PPP1R12C and MYL9/MLC2, CDC42BPB orchestrates the regulation of actin cytoskeletal reorganization, emphasizing its role in shaping cellular dynamics. Collaborating with MYO18A and LURAP1, CDC42BPB actively participates in the modulation of lamellar actomyosin retrograde flow, a process critical for cell protrusion and migration. Furthermore, CDC42BPB phosphorylates PPP1R12A, contributing to its multifaceted impact on cellular functions. In tandem with FAM89B/LRAP25, CDC42BPB facilitates the targeting of LIMK1 to the lamellipodium, initiating its activation and subsequent phosphorylation of CFL1, a crucial event for the regulation of lamellipodial F-actin dynamics.

Human

Sf9 insect cells

GST

Q9Y5S2 (S2-G473)

9578

Greater than 80 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.