MXRA8 Protein, Human (HEK293, His)

MXRA8 Protein, a transmembrane modulator, likely interacts with integrin ITGAV:ITGB3, influencing various signaling pathways. It inhibits osteoclastogenesis, promotes cartilage formation, and stimulates primary cilia formation in chondrocytes. In angiogenesis, it suppresses endothelial cell migration, promotes apoptosis, and inhibits VEGF-induced AKT and p38 MAP kinase activation. Additionally, MXRA8 may contribute to arthritogenic alphavirus pathogenesis as a viral receptor. MXRA8 Protein, Human (HEK293, His) is the recombinant human-derived MXRA8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MXRA8 Protein, Human (HEK293, His) is 322 a.a., with molecular weight of 40-53 kDa.

MXRA8, a transmembrane protein, exerts its regulatory influence on various signaling pathways, likely through interaction with integrin ITGAV:ITGB3. This interaction facilitates heterophilic cell-cell interactions and modulates osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, potentially by dampening signaling via integrin ITGB3 and MAP kinase p38. In the context of cartilage formation, MXRA8 promotes the proliferation and maturation of growth plate chondrocytes, stimulates primary cilia formation, and enhances the expression of hedgehog signaling pathway genes, including IHH. Furthermore, MXRA8 plays a role in angiogenesis by suppressing endothelial cell migration, promoting apoptosis, and inhibiting VEGF-induced activation of AKT and p38 MAP kinase. Additionally, MXRA8 inhibits integrin ITGAV:ITGB3 signaling and PTK2/FAK activation in response to VTN. It may also contribute to the maturation and maintenance of the blood-brain barrier. In the context of microbial infection, MXRA8 serves as a receptor for arthritogenic alphaviruses, contributing to their pathogenesis.

Human

HEK293

C-His

Q9BRK3-1 (V20-Q341)

/

40-53 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.