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MYOZ2 Protein, Human (His)

Cat. No.: HY-P70919
Handling Instructions

MYOZ2 is a member of the Myozenin family that binds to Z-line proteins, including α-actin and γ-filamin, and contributes to the localization of calcineurin signals within the sarcomere. It plays a key role in regulating calcineurin signaling and has been shown to be involved in muscle regulatory mechanisms and myofibril formation. MYOZ2 Protein, Human (His) is the recombinant human-derived MYOZ2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of MYOZ2 Protein, Human (His) is 264 a.a., with molecular weight of ~38.0 kDa.

For research use only. We do not sell to patients.

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Description

MYOZ2 is a member of the Myozenin family that binds to Z-line proteins, including α-actin and γ-filamin, and contributes to the localization of calcineurin signals within the sarcomere. It plays a key role in regulating calcineurin signaling and has been shown to be involved in muscle regulatory mechanisms and myofibril formation. MYOZ2 Protein, Human (His) is the recombinant human-derived MYOZ2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of MYOZ2 Protein, Human (His) is 264 a.a., with molecular weight of ~38.0 kDa.

Background

MYOZ2, a member of the Myozenin family, functions as an intracellular binding protein, facilitating the linkage of Z-line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, and LDB3/ZASP, thereby contributing to the localization of calcineurin signaling within the sarcomere. This protein is pivotal in modulating calcineurin signaling, suggesting its involvement in the intricate regulatory mechanisms of muscle function. Additionally, MYOZ2 may play a crucial role in myofibrillogenesis. Through its C-terminus, MYOZ2 interacts with spectrin repeats 3 and 4 of ACTN2, and it engages in interactions with other proteins, including ACTN1, LDB3, MYOT, and PPP3CA. These interactions highlight the significance of MYOZ2 in mediating molecular connections essential for the structural and signaling integrity of the sarcomere.

Species

Human

Source

E. coli

Tag

C-6*His

Accession

Q9NPC6 (M1-L264)

Gene ID
Molecular Construction
N-term
MYOZ2 (M1-L264)
Accession # Q9NPC6
6*His
C-term
Synonyms
Myozenin-2; Calsarcin-1; FATZ-Related Protein 2; MYOZ2; C4orf5
AA Sequence

MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL

Molecular Weight

Approximately 38.0 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

MYOZ2 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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MYOZ2 Protein, Human (His)
Cat. No.:
HY-P70919
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