NA/Neuraminidase Protein, H9N2 (Q9ICY2, HEK293, His)

The NA/Neuraminidase Protein, found on influenza virus surfaces, cleaves sialic acid residues. Inhibiting NA/Neuraminidase Protein is vital for antiviral drugs. Targeting NA/Neuraminidase Protein prevents viral release, reduces spread, and potentially treats influenza infections. NA/Neuraminidase Protein, H9N2 (Q9ICY2, HEK293, His) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by HEK293 , with N-His labeled tag. The total length of NA/Neuraminidase Protein, H9N2 (Q9ICY2, HEK293, His) is 434 a.a., with molecular weight of ~65.9 kDa.

The NA/Neuraminidase protein is responsible for catalyzing the removal of terminal sialic acid residues from both viral and cellular glycoconjugates. During virus budding, it cleaves off the terminal sialic acids on the glycosylated HA, allowing for the efficient release of the virus. Additionally, it aids in virus spread by removing sialic acids from the cell surface, preventing self-aggregation and ensuring the progeny virus can easily spread from cell to cell. This enzyme is known as a receptor-destroying enzyme as it cleaves a terminal sialic acid from cellular receptors. It may also contribute to the invasion of the upper airways by cleaving sialic acid moieties on airway epithelial cells' mucin. The NA protein is associated with lipid rafts during intracellular transport, potentially assisting in the budding process, and may have effects independent of raft-association as well. It also plays a role in determining host range restriction on replication and virulence, while its sialidase activity in late endosome/lysosome traffic appears to enhance virus replication.

Virus

HEK293

N-His

Q9ICY2 (H36-I469)

1460997  [NCBI]

Approximately 65.9 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.