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Neuroligin-3/NLGN3 Protein, Human (HEK293, His)

Cat. No.: HY-P76510
COA Handling Instructions

Neuroligin-3 (NLGN3) Protein, a cell surface protein, engages in cell-cell interactions by interacting with neurexin family members. It influences synapse function and signal transmission, potentially by clustering synaptic proteins. NLGN3 may facilitate initial synapse formation but is not indispensable for it. Additionally, it may participate in glia-glia or glia-neuron interactions during peripheral nervous system development. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins and DLG4/PSD-95. Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is the recombinant human-derived Neuroligin-3/NLGN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is 652 a.a., with molecular weight of 100-110 KDa.

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Description

Neuroligin-3 (NLGN3) Protein, a cell surface protein, engages in cell-cell interactions by interacting with neurexin family members. It influences synapse function and signal transmission, potentially by clustering synaptic proteins. NLGN3 may facilitate initial synapse formation but is not indispensable for it. Additionally, it may participate in glia-glia or glia-neuron interactions during peripheral nervous system development. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins and DLG4/PSD-95. Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is the recombinant human-derived Neuroligin-3/NLGN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is 652 a.a., with molecular weight of 100-110 KDa.

Background

Neuroligin-3 (NLGN3) is a cell surface protein that plays a crucial role in cell-cell interactions through its interactions with neurexin family members. It is involved in synapse function and synaptic signal transmission, potentially by clustering other synaptic proteins. While NLGN3 may promote the initial formation of synapses, it is not essential for this process. Additionally, it may be involved in glia-glia or glia-neuron interactions in the developing peripheral nervous system. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins NRXN1, NRXN2, and NRXN3, with the interaction being mediated by heparan sulfate glycan modification on neurexin. Furthermore, NLGN3 interacts with DLG4/PSD-95 through its C-terminus, specifically with the PDZ domain 3 of DLG4/PSD-95.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q9NZ94-2 (Q38-S689)

Gene ID
Molecular Construction
N-term
NLGN3 (Q38-S689)
Accession # Q9NZ94-2
His
C-term
Synonyms
Neuroligin-3; Gliotactin homolog; KIAA1480; NL3; NLGN3
AA Sequence

MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELS

Molecular Weight

100-110 kDa.

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

Neuroligin-3/NLGN3 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Neuroligin-3/NLGN3 Protein, Human (HEK293, His)
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HY-P76510
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