Nicastrin Protein, Mouse (HEK293, hFc)

Nicastrin is an important subunit of the γ-secretase complex and plays a key role in the endoproteolytic cleavage of integral membrane proteins, including Notch receptors and amyloid-β precursor protein (APP). In the γ-secretase complex, nicastin acts as a key regulator of Notch and Wnt signaling cascades and affects downstream processes. Nicastrin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Nicastrin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Nicastrin Protein, Mouse (HEK293, hFc) is 641 a.a., with molecular weight of ~117 kDa.

Nicastrin, an indispensable subunit of the gamma-secretase complex, takes center stage in the intricate molecular machinery responsible for the endoproteolytic cleavage of integral membrane proteins. This includes pivotal substrates like Notch receptors and the amyloid-beta precursor protein (APP). The gamma-secretase complex, in which Nicastrin plays a crucial role, serves as a linchpin in the modulation of Notch and Wnt signaling cascades, exerting regulatory influence on downstream processes. In concert with other essential components, such as a presenilin homodimer, APH1, and PEN2, Nicastrin forms the functional gamma-secretase complex. Nicastrin's binding affinity extends to the proteolytically processed C-terminal fragments of APP, further underscoring its pivotal role in orchestrating the intricacies of this proteolytic machinery. Moreover, Nicastrin's interactions with presenilin components accentuate its integral role within the gamma-secretase complex.

Mouse

HEK293

C-hFc

P57716 (G28-E668)

59287  [NCBI]

Approximately 117 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.