Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His)

Nogo Receptor/NgR Protein functions as a versatile receptor for RTN4, OMG, and MAG, broadening its recognition to include sialylated gangliosides GT1b and GM1, chondroitin sulfate proteoglycans, and heparin. NGFR coreceptor activation initiates Rho-mediated actin cytoskeleton reorganization, leading to axonal growth inhibition. NgR plays a crucial role in axon regeneration and neuronal plasticity in the adult central nervous system, contributing to postnatal brain development, axon migration, and corpus callosum formation. It also protects motoneurons against apoptosis, potentially mediated by its interaction with MAG. Collaborating with RTN4 and LINGO1, NgR regulates neuronal precursor cell motility during cortical development. As a homodimer, it engages in a complex molecular network with OMG, MAG, RTN4, NGFR, LINGO1, KIAA0319L, and OLFM1, revealing its multifaceted roles in cellular processes and neural development. Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Nogo Receptor/NgR protein, expressed by HEK293, with C-His labeled tag. The total length of Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is 421 a.a., with molecular weight of 60-73 kDa.

Nogo Receptor/NgR Protein serves as a receptor for RTN4, OMG, and MAG, extending its functional repertoire to include recognition of sialylated gangliosides GT1b and GM1, chondroitin sulfate proteoglycans, and heparin. The activation of intracellular signaling cascades through the NGFR coreceptor triggers Rho-mediated downstream reorganization of the actin cytoskeleton, leading to axonal growth inhibition. This protein likely plays a crucial role in regulating axon regeneration and neuronal plasticity within the adult central nervous system, contributing to postnatal brain development, axon migration, and corpus callosum formation. Nogo Receptor/NgR also exhibits a protective effect on motoneurons against apoptosis, potentially mediated through its interaction with MAG. Collaborating with RTN4 and LINGO1, it participates in the regulation of neuronal precursor cell motility during cortical development. Moreover, akin to other family members, it is implicated in the control of dendritic spine and synapse numbers during brain development. Operating as a homodimer, Nogo Receptor/NgR engages in a complex network of molecular interactions with various partners, including OMG, MAG, RTN4, NGFR, LINGO1, KIAA0319L, and OLFM1, further elucidating its multifaceted roles in cellular processes and neural development.

Cynomolgus

HEK293

C-His

Q9N0E3 (C27-S447)

102139327  [NCBI]

60-73 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.