Neuregulin-2/NRG2 Protein, Human (HEK293, His)

Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuregulin-2/NRG2 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~34 kDa.

Neuregulin-2 (NRG2) functions as a direct ligand for the tyrosine kinase receptors ERBB3 and ERBB4. Upon binding, NRG2 facilitates the recruitment of ERBB1 and ERBB2 coreceptors, leading to ligand-induced tyrosine phosphorylation and activation of the ERBB receptors. Additionally, NRG2 may promote heterodimerization with the EGF receptor. This intricate interaction with ERBB family members suggests a role for NRG2 in modulating diverse cellular processes through the activation of downstream signaling pathways. The binding and activation of ERBB receptors by NRG2 underscore its significance in cellular communication and signal transduction, highlighting its potential involvement in various physiological and developmental contexts.

Human

HEK293

C-His

O14511 (C112-K404)

9542  [NCBI]

Approximately 34 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.