1. Recombinant Proteins
  2. OX40 Ligand/TNFSF4 Protein, Human (HEK293)

OX40 Ligand/TNFSF4 Protein, Human (HEK293)

Cat. No.: HY-P700306
Handling Instructions

OX40 Ligand/TNFSF4 Protein, a cytokine, binds specifically to TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. Operating as a homotrimer, its engagement enhances immune response by activating and expanding T-cells. The interaction with TNFRSF4 contributes to intricate regulation, crucial for modulating T-cell functions and achieving effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Human (HEK293) is the recombinant human-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293 , with tag free. The total length of OX40 Ligand/TNFSF4 Protein, Human (HEK293) is 133 a.a., with molecular weight of 65-140 kDa.

For research use only. We do not sell to patients.

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Description

OX40 Ligand/TNFSF4 Protein, a cytokine, binds specifically to TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. Operating as a homotrimer, its engagement enhances immune response by activating and expanding T-cells. The interaction with TNFRSF4 contributes to intricate regulation, crucial for modulating T-cell functions and achieving effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Human (HEK293) is the recombinant human-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293 , with tag free. The total length of OX40 Ligand/TNFSF4 Protein, Human (HEK293) is 133 a.a., with molecular weight of 65-140 kDa.

Background

The OX40 Ligand/TNFSF4 Protein, a cytokine, specifically binds to TNFRSF4 and functions as a potent co-stimulator for T-cell proliferation and cytokine production. Operating as a homotrimer, its engagement with TNFRSF4 serves to enhance the immune response by promoting the activation and expansion of T-cells. The interaction between OX40 Ligand and its receptor TNFRSF4 contributes to the intricate regulation of T-cell-mediated immune responses, playing a crucial role in modulating T-cell functions for an effective and controlled immune activation.

Species

Human

Source

HEK293

Tag

Tag Free

Accession

P23510-1 (Q51-L183)

Gene ID

7292

Molecular Construction
N-term
OX40L (Q51-L183)
Accession # P23510
C-term
Synonyms
OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L;  TXGP1; Glycoprotein Gp34
AA Sequence

QVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL

Molecular Weight

Approximately 19-27 kDa

Purity

Greater than 95% as determined by SDS-PAGE.

Endotoxin Level

<0.1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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OX40 Ligand/TNFSF4 Protein, Human (HEK293)
Cat. No.:
HY-P700306
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