PACSIN2 Protein, Human (HEK293, His)

The PACSIN2 protein coordinates caveolar morphogenesis and endocytosis to dynamically regulate cell membrane structure. As a lipid-binding protein, PACSIN2 regulates phosphatidic acid-containing membranes. PACSIN2 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN2 protein, expressed by HEK293 , with C-6*His labeled tag.

PACSIN2 protein plays a pivotal role in orchestrating the morphogenesis and endocytosis of caveolae, contributing to the dynamic regulation of cellular membrane structures. Functioning as a lipid-binding protein, PACSIN2 exhibits a particular affinity for phosphatidic acid-containing membranes, promoting their tubulation. Beyond its involvement in membrane shaping, PACSIN2 serves a crucial function in intracellular vesicle-mediated transport, facilitating the endocytosis of cell-surface receptors such as the EGF receptor, even in the absence of EGF stimulus. Furthermore, PACSIN2 demonstrates a multifaceted role in microbial infection, notably enhancing the efficiency of HIV-1 virion spread through cell-to-cell transfer and promoting protrusion engulfment during the cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Additionally, PACSIN2 contributes to lipid droplet formation, a process vital for HCV virion assembly. Overall, PACSIN2 emerges as a versatile regulator with significant implications in membrane dynamics, cellular transport, and infectious processes.

Human

HEK293

C-6*His

Q9UNF0-1 (M1-Q486)

11252  [NCBI]

MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ

Approximately 88.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.