PDE1B Protein, Human (sf9, His-GST)

PDE1B protein, a cyclic nucleotide phosphodiesterase, displays dual specificity for cAMP and cGMP, essential second messengers in physiological processes. Preferring cGMP as a substrate, PDE1B fine-tunes cellular responses to cyclic nucleotide signaling. Its dual specificity underscores its regulatory role in diverse physiological pathways. PDE1B Protein, Human (sf9, His-GST) is the recombinant human-derived PDE1B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE1B Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~75 kDa.

PDE1B protein functions as a cyclic nucleotide phosphodiesterase with dual specificity for the second messengers cAMP and cGMP, both crucial regulators in various physiological processes. This enzyme exhibits a preference for cGMP as a substrate, contributing to its role in modulating intracellular signaling mediated by cyclic nucleotides. The dual specificity of PDE1B underscores its importance in fine-tuning cellular responses to cyclic nucleotide signaling, thereby playing a regulatory role in diverse physiological pathways.

Human

Sf9 insect cells

N-His;N-GST

Q01064 (M1-D536)

5153  [NCBI]

Approximately 75 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.