2. Gene
  3. PDE1B - phosphodiesterase 1B Gene

PDE1B - phosphodiesterase 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PDE1B1; PDES1B; HEL-S-79p

Gene ID: 5153 | Gene type: protein coding

About PDE1B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,549,601-54,579,239 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 20 paralogues. Broad expression in brain (RPKM 8.5), fat (RPKM 6.8) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE1B Products(6)

mRNA Protein Name
NM_000924.4 NP_000915.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1
NM_001165975.3 NP_001159447.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2
NM_001288768.2 NP_001275697.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001288769.2 NP_001275698.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 4
NM_001315534.2 NP_001302463.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001315535.2 NP_001302464.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
14687666 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
8855339 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
14687666 GOA
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9419816 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in cellular response to macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in monocyte differentiation IEP
IEP: Inferred from expression pattern
14687666 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
8855339 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE1B Protein Structure

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (77 - 137)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (222 - 450)

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  • 536 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

63 kDa Cam-PDE

PDE1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PDE1B Q01064 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE1B Proteins

Cat. No. Product Name Accession Purity
HY-P75960 PDE1B Protein, Human (sf9, His-GST) Q01064 (M1-D536) ≥95%

PDE1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P81808 PDE1B Antibody (YA1553) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.19% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% Unkown
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE1B VGNC VGNC:68753
Mus musculus PDE1B MGD MGI:97523
Canis familiaris PDE1B VGNC VGNC:44349
Macaca mulatta PDE1B VGNC VGNC:75910
Rattus norvegicus PDE1B RGD RGD:3278
Bos taurus PDE1B VGNC VGNC:32672
Others PDE1B NCBI