2. Gene
  3. PDE1B - phosphodiesterase 1B Gene

PDE1B - phosphodiesterase 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PDE1B1; PDES1B; HEL-S-79p

Gene ID: 5153 | Gene type: protein coding

About PDE1B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,549,601-54,579,239 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 20 paralogues. Broad expression in brain (RPKM 8.5), fat (RPKM 6.8) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE1B Products(6)

mRNA Protein Name
NM_000924.4 NP_000915.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1
NM_001165975.3 NP_001159447.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2
NM_001288768.2 NP_001275697.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001288769.2 NP_001275698.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 4
NM_001315534.2 NP_001302463.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001315535.2 NP_001302464.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 5

PDE1B Protein Structure

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (77 - 137)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (222 - 450)

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  • 536 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

63 kDa Cam-PDE

Recombinant PDE1B Proteins

Cat. No. Product Name Accession Purity
HY-P75960 PDE1B Protein, Human (sf9, His-GST) Q01064 (M1-D536) ≥95%

Related Diseases

Diseases Alias
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Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

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Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.19% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% Unkown
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120741 PF-04822163 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE1B VGNC VGNC:68753
Mus musculus PDE1B MGD MGI:97523
Canis familiaris PDE1B VGNC VGNC:44349
Macaca mulatta PDE1B VGNC VGNC:75910
Rattus norvegicus PDE1B RGD RGD:3278
Bos taurus PDE1B VGNC VGNC:32672
Others PDE1B NCBI