PDE9A Protein, Human (His)

PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (His) is the recombinant human-derived PDE9A protein, expressed by E. coli , with N-His labeled tag. The total length of PDE9A Protein, Human (His) is 326 a.a., with molecular weight of ~37 kDa.

PDE9A, a phosphodiesterase enzyme, exhibits remarkable specificity by hydrolyzing the second messenger cwith the highest affinity and selectivity compared to other members of the cyclic nucleotide phosphodiesterase family. Its distinctive role is evident in regulating natriuretic-peptide-dependent csignaling in the heart, where it serves as a key regulator of cardiac hypertrophy in myocytes and muscle. Notably, PDE9A does not influence nitric oxide-dependent csignaling in the heart, highlighting its specificity for natriuretic-peptide-dependent pathways. Further investigations are warranted to determine whether its role in hydrolyzing natriuretic-peptide-dependent cis exclusive to the heart or represents a broader feature of the protein. Additionally, in the brain, PDE9A contributes to cognitive functions such as learning and long-term memory, emphasizing its diverse physiological roles in different tissues.

Human

E. coli

N-His

O76083-2 (P181-K506)

5152  [NCBI]

Approximately 37 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.